Skip to main content

N of 1 trials and the individualization of drug treatments

The ultimate goal of evidence based medicine is the provision of care for the individual patient using the best evidence. The responsibility falls on the clinician to determine what is best for the individual patient, and also on the patient to use the prescribed drugs appropriately. In an attempt to prove the effectiveness of their medications patients have been known to adjust their drug treatment by increasing or decreasing doses and clinicians have also been known to perform trials of therapy in circumstances where there is insufficient evidence-based information for the treatment of an individual patient. Therefore, there is need for a standardized approach to determining treatment effect in the individual patient. The N-of-1 trial provides a means of determining individualised treatment for a patient. They are single-subject, multiple crossover trials where participants are switched periodically from active to control (standard care, placebo) or between active treatments (2 or more) or between several doses of a treatment.

This project aims to provide a detailed typology of N of 1 designs; assess the particular challenges that N of 1 trials can address, and for which conditions N of 1 trials are most useful; and determine if N of 1 trials is an effective way of determining treatment for a patient.

The first phase of the project involves a systematic review of N-of-1 trials, which will help to answer above questions. Second phase involves a survey or interviews with clinicians involved in N-of-1 trials to determine its clinical application.

For more information, please read the project proposal.

If you’d like to learn more, please contact Weyinmi Demeyin via Email

Upcoming Events

Jun
29

Searching and Review Clinic

The University of Exeter, St Luke's campus, South Cloisters (Room 2.35)

These clinics have been set up to help the PenCLAHRC Evidence Synthesis Team to manage and respond...
More information

Jul
13

Searching and Review Clinic

ITTC Building, Plymouth Science Park (Room N14)

These clinics have been set up to help the PenCLAHRC Evidence Synthesis Team to manage and respond...
More information

Calendar

News

Prisoner mental health collaboration receives extension and funding boost

23 June 2017

A national collaboration supported by PenCLAHRC, investigating ways to support prisoners with mental health problems both...
Read more

Starting school young can put child wellbeing at risk

22 June 2017

New research, supported by PenCLAHRC, has shown that the youngest pupils in each school year...
Read more

Carers speak about helping to shape research and education

16 June 2017

Carers have spoken about the value of sharing their experiences with students and researchers at...
Read more

News

Research Projects

Public involvement in suicide prevention

Theme: Mental Health & Dementia

A research programme examining a public health intervention designed to help members of the public...
Read more

PenCHORD: Modelling the optimal size of Derriford Ambulatory Care Unit (ACU)

Theme: Evidence for Policy and Practice

Providing modelling evidence of the optimal size for an expanded Ambulatory Care Unit (ACU) at...
Read more

Research Projects