- Research and Projects
- Get Involved
The ultimate goal of evidence based medicine is the provision of care for the individual patient using the best evidence. The responsibility falls on the clinician to determine what is best for the individual patient, and also on the patient to use the prescribed drugs appropriately. In an attempt to prove the effectiveness of their medications patients have been known to adjust their drug treatment by increasing or decreasing doses and clinicians have also been known to perform trials of therapy in circumstances where there is insufficient evidence-based information for the treatment of an individual patient. Therefore, there is need for a standardized approach to determining treatment effect in the individual patient. The N-of-1 trial provides a means of determining individualised treatment for a patient. They are single-subject, multiple crossover trials where participants are switched periodically from active to control (standard care, placebo) or between active treatments (2 or more) or between several doses of a treatment.
This project aims to provide a detailed typology of N of 1 designs; assess the particular challenges that N of 1 trials can address, and for which conditions N of 1 trials are most useful; and determine if N of 1 trials is an effective way of determining treatment for a patient.
The first phase of the project involves a systematic review of N-of-1 trials, which will help to answer above questions. Second phase involves a survey or interviews with clinicians involved in N-of-1 trials to determine its clinical application.
For more information, please read the project proposal.
Demeyin WA, Frost J, Ukoumunne OC, Briscoe S, Britten N (2017). N of 1 trials and the optimal individualisation of drug treatments: a systematic review protocol. Systematic Reviews 6(90)
21 June 2018
Learning to manage going to the toilet independently is an
important milestone in child development....
19 June 2018
Hypnosis could help to reduce the fear of medical procedures in
children and young people...
15 June 2018
The University of Plymouth are looking to recruit a
Research Fellow (Information Specialist) within PenCLAHRC. The
key purpose of...
Theme: Diagnostics & Stratified Medicine
How can we help GPs make better use of thyroid function tests?
Theme: Person-Centred Care
This project aims to offer a structured approach for GP trainees to
manage consultations with...