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Theme: Evidence for Policy and Practice
“A post-antibiotic era—in which common infections and minor injuries can kill—far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century”
Dr Keiji Fukuda, World Health Organisation (WHO) Assistant Director-General.
Anti-Microbial Resistance (AMR) is the ability of microorganisms that cause disease to withstand attack by antimicrobial medicines. AMR is also costly, estimated at US$21-34 billion dollars per annum in the USA. The consequences extend beyond patients who present with infections. Many surgical procedures (where antibiotics are given prophylactically in the hope of preventing infections) may be harder to justify as the risk and consequences of infection become more likely and serious.
There are two important strands of activity to address this global crisis. The first is to develop new antimicrobials, the second is to urge all countries to be more prudent in their use of antimicrobials - this is the focus of our proposed research. Antimicrobial stewardship aims to promote optimal care for patients with infections, whilst minimising the public health threat of drug resistance. However, changing prescribing behaviour is difficult and the challenge is significant given that less than 50% of antibiotic usage in hospitals is inappropriate.
The development of antimicrobial resistance has been described as a global crisis - more prudent prescribing is part of the solution. Behaviour change interventions are urgently needed to improve prescribing practice. Presently, the literature documents that context impacts on prescribing decisions. Yet minimal tailoring of interventions by context or grade of prescriber, makes it hard for researchers and policy makers to draw firm conclusions or make recommendations about ‘what works’, ‘for whom’, ‘in what circumstances’, ‘how’ and ‘why’ in their context. Doctors in training are an important group to study, being numerically the largest group of prescribers in UK hospitals. Unfortunately very few interventions have specifically targeted this group.
To understand how interventions to change antimicrobial prescribing behaviours of doctors in training produce their effects.
The project will produce three major types of outputs:
This project was funded by NIHR HS&DR (12/97/24)
For more information, view the protocol.
University of Oxford – Geoff Wong, Chrysanthi Papoutsi
University of Plymouth – Nicola Brennan